human alpha cells Search Results


tumor necrosis factor alpha tnf α  (Shanghai Korain Biotech Co Ltd)
93
Shanghai Korain Biotech Co Ltd tumor necrosis factor alpha tnf α
Tumor Necrosis Factor Alpha Tnf α, supplied by Shanghai Korain Biotech Co Ltd, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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l methionine  (Chem Impex International)
95
Chem Impex International l methionine
L Methionine, supplied by Chem Impex International, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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bcl2  (Boster Bio)
96
Boster Bio bcl2
Fig. 1. Loss of Npc1 impairs brain development in mouse. A Representative photograph of brain from Npc1−/−mice and littermate control at postnatal day 63 (P63). B Brain weight curves of Npc1−/−mice and littermate controls (n = 9; Page x genotype < 0.0001, Page < 0.0001, Pgenotype < 0.0001). C Representative coronal sections of Npc1−/−mice and littermate controls at P42 visualized by hematoxylin and eosin staining. D Quantification of the cortical thickness of mice from P1 to P63 (n = 3). E, F Representative confocal images and quantification of Filipin (white) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). G, H Representative confocal images and quantification of GFAP (red) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). I, J Repre sentative confocal images and quantification of MBP (green) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). K, L Representative confocal images and quantification of cleaved-Caspase3 (c.CASP3, green) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). M Western blot analysis for c.CASP3, BAX and <t>BCL2</t> protein expression in the brain of Npc1−/−mice and littermate controls (n = 3). Results are presented as Mean ± SEM. n.s., not sig nificant. *P < 0.05, **P < 0.01 and ***P < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Bcl2, supplied by Boster Bio, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cd8  (Boster Bio)
94
Boster Bio cd8
Fig. 1. Loss of Npc1 impairs brain development in mouse. A Representative photograph of brain from Npc1−/−mice and littermate control at postnatal day 63 (P63). B Brain weight curves of Npc1−/−mice and littermate controls (n = 9; Page x genotype < 0.0001, Page < 0.0001, Pgenotype < 0.0001). C Representative coronal sections of Npc1−/−mice and littermate controls at P42 visualized by hematoxylin and eosin staining. D Quantification of the cortical thickness of mice from P1 to P63 (n = 3). E, F Representative confocal images and quantification of Filipin (white) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). G, H Representative confocal images and quantification of GFAP (red) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). I, J Repre sentative confocal images and quantification of MBP (green) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). K, L Representative confocal images and quantification of cleaved-Caspase3 (c.CASP3, green) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). M Western blot analysis for c.CASP3, BAX and <t>BCL2</t> protein expression in the brain of Npc1−/−mice and littermate controls (n = 3). Results are presented as Mean ± SEM. n.s., not sig nificant. *P < 0.05, **P < 0.01 and ***P < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Cd8, supplied by Boster Bio, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti tnf α  (Cell Signaling Technology Inc)
94
Cell Signaling Technology Inc anti tnf α
Fig. 1. Loss of Npc1 impairs brain development in mouse. A Representative photograph of brain from Npc1−/−mice and littermate control at postnatal day 63 (P63). B Brain weight curves of Npc1−/−mice and littermate controls (n = 9; Page x genotype < 0.0001, Page < 0.0001, Pgenotype < 0.0001). C Representative coronal sections of Npc1−/−mice and littermate controls at P42 visualized by hematoxylin and eosin staining. D Quantification of the cortical thickness of mice from P1 to P63 (n = 3). E, F Representative confocal images and quantification of Filipin (white) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). G, H Representative confocal images and quantification of GFAP (red) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). I, J Repre sentative confocal images and quantification of MBP (green) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). K, L Representative confocal images and quantification of cleaved-Caspase3 (c.CASP3, green) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). M Western blot analysis for c.CASP3, BAX and <t>BCL2</t> protein expression in the brain of Npc1−/−mice and littermate controls (n = 3). Results are presented as Mean ± SEM. n.s., not sig nificant. *P < 0.05, **P < 0.01 and ***P < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Anti Tnf α, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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alpha satellite repeats  (Cell Signaling Technology Inc)
94
Cell Signaling Technology Inc alpha satellite repeats
Fig. 1. Loss of Npc1 impairs brain development in mouse. A Representative photograph of brain from Npc1−/−mice and littermate control at postnatal day 63 (P63). B Brain weight curves of Npc1−/−mice and littermate controls (n = 9; Page x genotype < 0.0001, Page < 0.0001, Pgenotype < 0.0001). C Representative coronal sections of Npc1−/−mice and littermate controls at P42 visualized by hematoxylin and eosin staining. D Quantification of the cortical thickness of mice from P1 to P63 (n = 3). E, F Representative confocal images and quantification of Filipin (white) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). G, H Representative confocal images and quantification of GFAP (red) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). I, J Repre sentative confocal images and quantification of MBP (green) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). K, L Representative confocal images and quantification of cleaved-Caspase3 (c.CASP3, green) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). M Western blot analysis for c.CASP3, BAX and <t>BCL2</t> protein expression in the brain of Npc1−/−mice and littermate controls (n = 3). Results are presented as Mean ± SEM. n.s., not sig nificant. *P < 0.05, **P < 0.01 and ***P < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Alpha Satellite Repeats, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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recombinant human tgf 1  (Cell Signaling Technology Inc)
93
Cell Signaling Technology Inc recombinant human tgf 1
Fig. 1. Loss of Npc1 impairs brain development in mouse. A Representative photograph of brain from Npc1−/−mice and littermate control at postnatal day 63 (P63). B Brain weight curves of Npc1−/−mice and littermate controls (n = 9; Page x genotype < 0.0001, Page < 0.0001, Pgenotype < 0.0001). C Representative coronal sections of Npc1−/−mice and littermate controls at P42 visualized by hematoxylin and eosin staining. D Quantification of the cortical thickness of mice from P1 to P63 (n = 3). E, F Representative confocal images and quantification of Filipin (white) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). G, H Representative confocal images and quantification of GFAP (red) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). I, J Repre sentative confocal images and quantification of MBP (green) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). K, L Representative confocal images and quantification of cleaved-Caspase3 (c.CASP3, green) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). M Western blot analysis for c.CASP3, BAX and <t>BCL2</t> protein expression in the brain of Npc1−/−mice and littermate controls (n = 3). Results are presented as Mean ± SEM. n.s., not sig nificant. *P < 0.05, **P < 0.01 and ***P < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Recombinant Human Tgf 1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cd11b mac 1  (Boster Bio)
93
Boster Bio cd11b mac 1
Fig. 1. Loss of Npc1 impairs brain development in mouse. A Representative photograph of brain from Npc1−/−mice and littermate control at postnatal day 63 (P63). B Brain weight curves of Npc1−/−mice and littermate controls (n = 9; Page x genotype < 0.0001, Page < 0.0001, Pgenotype < 0.0001). C Representative coronal sections of Npc1−/−mice and littermate controls at P42 visualized by hematoxylin and eosin staining. D Quantification of the cortical thickness of mice from P1 to P63 (n = 3). E, F Representative confocal images and quantification of Filipin (white) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). G, H Representative confocal images and quantification of GFAP (red) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). I, J Repre sentative confocal images and quantification of MBP (green) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). K, L Representative confocal images and quantification of cleaved-Caspase3 (c.CASP3, green) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). M Western blot analysis for c.CASP3, BAX and <t>BCL2</t> protein expression in the brain of Npc1−/−mice and littermate controls (n = 3). Results are presented as Mean ± SEM. n.s., not sig nificant. *P < 0.05, **P < 0.01 and ***P < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Cd11b Mac 1, supplied by Boster Bio, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti human iga  (Cell Signaling Technology Inc)
91
Cell Signaling Technology Inc anti human iga
Fig. 1. Loss of Npc1 impairs brain development in mouse. A Representative photograph of brain from Npc1−/−mice and littermate control at postnatal day 63 (P63). B Brain weight curves of Npc1−/−mice and littermate controls (n = 9; Page x genotype < 0.0001, Page < 0.0001, Pgenotype < 0.0001). C Representative coronal sections of Npc1−/−mice and littermate controls at P42 visualized by hematoxylin and eosin staining. D Quantification of the cortical thickness of mice from P1 to P63 (n = 3). E, F Representative confocal images and quantification of Filipin (white) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). G, H Representative confocal images and quantification of GFAP (red) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). I, J Repre sentative confocal images and quantification of MBP (green) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). K, L Representative confocal images and quantification of cleaved-Caspase3 (c.CASP3, green) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). M Western blot analysis for c.CASP3, BAX and <t>BCL2</t> protein expression in the brain of Npc1−/−mice and littermate controls (n = 3). Results are presented as Mean ± SEM. n.s., not sig nificant. *P < 0.05, **P < 0.01 and ***P < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Anti Human Iga, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human alpha cells  (Celprogen Inc)
90
Celprogen Inc human alpha cells
Fig. 1. Loss of Npc1 impairs brain development in mouse. A Representative photograph of brain from Npc1−/−mice and littermate control at postnatal day 63 (P63). B Brain weight curves of Npc1−/−mice and littermate controls (n = 9; Page x genotype < 0.0001, Page < 0.0001, Pgenotype < 0.0001). C Representative coronal sections of Npc1−/−mice and littermate controls at P42 visualized by hematoxylin and eosin staining. D Quantification of the cortical thickness of mice from P1 to P63 (n = 3). E, F Representative confocal images and quantification of Filipin (white) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). G, H Representative confocal images and quantification of GFAP (red) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). I, J Repre sentative confocal images and quantification of MBP (green) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). K, L Representative confocal images and quantification of cleaved-Caspase3 (c.CASP3, green) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). M Western blot analysis for c.CASP3, BAX and <t>BCL2</t> protein expression in the brain of Npc1−/−mice and littermate controls (n = 3). Results are presented as Mean ± SEM. n.s., not sig nificant. *P < 0.05, **P < 0.01 and ***P < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Human Alpha Cells, supplied by Celprogen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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recombinant human tnf α  (Cell Signaling Technology Inc)
94
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Fig. 1. Loss of Npc1 impairs brain development in mouse. A Representative photograph of brain from Npc1−/−mice and littermate control at postnatal day 63 (P63). B Brain weight curves of Npc1−/−mice and littermate controls (n = 9; Page x genotype < 0.0001, Page < 0.0001, Pgenotype < 0.0001). C Representative coronal sections of Npc1−/−mice and littermate controls at P42 visualized by hematoxylin and eosin staining. D Quantification of the cortical thickness of mice from P1 to P63 (n = 3). E, F Representative confocal images and quantification of Filipin (white) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). G, H Representative confocal images and quantification of GFAP (red) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). I, J Repre sentative confocal images and quantification of MBP (green) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). K, L Representative confocal images and quantification of cleaved-Caspase3 (c.CASP3, green) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). M Western blot analysis for c.CASP3, BAX and <t>BCL2</t> protein expression in the brain of Npc1−/−mice and littermate controls (n = 3). Results are presented as Mean ± SEM. n.s., not sig nificant. *P < 0.05, **P < 0.01 and ***P < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Recombinant Human Tnf α, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human recombinant interferon α1  (Cell Signaling Technology Inc)
93
Cell Signaling Technology Inc human recombinant interferon α1
Fig. 1. Loss of Npc1 impairs brain development in mouse. A Representative photograph of brain from Npc1−/−mice and littermate control at postnatal day 63 (P63). B Brain weight curves of Npc1−/−mice and littermate controls (n = 9; Page x genotype < 0.0001, Page < 0.0001, Pgenotype < 0.0001). C Representative coronal sections of Npc1−/−mice and littermate controls at P42 visualized by hematoxylin and eosin staining. D Quantification of the cortical thickness of mice from P1 to P63 (n = 3). E, F Representative confocal images and quantification of Filipin (white) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). G, H Representative confocal images and quantification of GFAP (red) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). I, J Repre sentative confocal images and quantification of MBP (green) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). K, L Representative confocal images and quantification of cleaved-Caspase3 (c.CASP3, green) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). M Western blot analysis for c.CASP3, BAX and <t>BCL2</t> protein expression in the brain of Npc1−/−mice and littermate controls (n = 3). Results are presented as Mean ± SEM. n.s., not sig nificant. *P < 0.05, **P < 0.01 and ***P < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Human Recombinant Interferon α1, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Fig. 1. Loss of Npc1 impairs brain development in mouse. A Representative photograph of brain from Npc1−/−mice and littermate control at postnatal day 63 (P63). B Brain weight curves of Npc1−/−mice and littermate controls (n = 9; Page x genotype < 0.0001, Page < 0.0001, Pgenotype < 0.0001). C Representative coronal sections of Npc1−/−mice and littermate controls at P42 visualized by hematoxylin and eosin staining. D Quantification of the cortical thickness of mice from P1 to P63 (n = 3). E, F Representative confocal images and quantification of Filipin (white) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). G, H Representative confocal images and quantification of GFAP (red) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). I, J Repre sentative confocal images and quantification of MBP (green) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). K, L Representative confocal images and quantification of cleaved-Caspase3 (c.CASP3, green) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). M Western blot analysis for c.CASP3, BAX and BCL2 protein expression in the brain of Npc1−/−mice and littermate controls (n = 3). Results are presented as Mean ± SEM. n.s., not sig nificant. *P < 0.05, **P < 0.01 and ***P < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

Journal: Biochimica et biophysica acta. Molecular basis of disease

Article Title: Npc1 deficiency impairs microglia function via TREM2-mTOR signaling in Niemann-Pick disease type C.

doi: 10.1016/j.bbadis.2024.167478

Figure Lengend Snippet: Fig. 1. Loss of Npc1 impairs brain development in mouse. A Representative photograph of brain from Npc1−/−mice and littermate control at postnatal day 63 (P63). B Brain weight curves of Npc1−/−mice and littermate controls (n = 9; Page x genotype < 0.0001, Page < 0.0001, Pgenotype < 0.0001). C Representative coronal sections of Npc1−/−mice and littermate controls at P42 visualized by hematoxylin and eosin staining. D Quantification of the cortical thickness of mice from P1 to P63 (n = 3). E, F Representative confocal images and quantification of Filipin (white) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). G, H Representative confocal images and quantification of GFAP (red) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). I, J Repre sentative confocal images and quantification of MBP (green) and DAPI (blue) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). K, L Representative confocal images and quantification of cleaved-Caspase3 (c.CASP3, green) staining in the cortex of Npc1+/+ and Npc1−/−mice at P42 (n = 3). M Western blot analysis for c.CASP3, BAX and BCL2 protein expression in the brain of Npc1−/−mice and littermate controls (n = 3). Results are presented as Mean ± SEM. n.s., not sig nificant. *P < 0.05, **P < 0.01 and ***P < 0.001. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)

Article Snippet: The primary and secondary antibodies were used as follows: cleaved-Caspase3 (Cell Signaling Technology, USA; Cat No. 9664), BAX (Cell Signaling Technology, USA; Cat No. 14796), BCL2 (BOSTER, China; Cat No. BA0412), APOE (Abcam, UK; Cat No. ab183597), CTSD (Abcam, UK; Cat No. ab75852), Npc1 (Abcam, UK; Cat No. ab134113), Npc2 (Abcam, UK; Cat No. ab218192), TREM2 (Cell Signaling Technology, USA; Cat No. 76765), TREM2 (R&D Systems, USA; Cat No. AF1729), TREM2 (Abcam, UK; Cat No. ab305103), SYK (Cell Signaling Technology, USA; Cat No.13198), p-SYK (Cell Signaling Technology, USA; Cat No.2710), AKT (Cell Signaling Technology, USA; Cat No.4691), p-AKT (Cell Signaling Technology, USA; Cat No.13038), GSK3β (Cell Signaling Technology, USA; Cat No. 12456), p-GSK3β (Cell Signaling Technology, USA; Cat No. 5558), mTOR (Cell Signaling Technology, USA; Cat No. 2983), p-mTOR (Cell Signaling Technology, USA; Cat No. 5536), S6K1 (Cell Signaling Technology, USA; Cat No. 34475), p-S6K1 (Cell Signaling Technology, USA; Cat No. 9234), 4EBP1 (Cell Signaling Technology, USA; Cat No. 9644), p-4EBP1 (Cell Signaling Technology, USA; Cat No. 9451), CD63 (Abcam, UK; Cat No. ab217345), GFAP (Cell Signaling Technology, USA; Cat No. 80788), β-Actin (Affinity Biosciences, USA; Cat No. AF7018), β-Tubulin (Absin, China; Cat No. abs830032), Goat anti-Rabbit IgG-HRP (Absin, China; Cat No. abs20040), Goat anti-Mouse IgG-HRP (Absin, China; Cat No. abs20039), Rabbit anti-Sheep IgG-HRP (Abcam, UK; Cat No. ab6747).

Techniques: Control, Staining, Western Blot, Expressing